Cardiovascular study

Aim/objective
We correlated serum levels of oxidized low-density lipoprotein b2-glycoprotein I complex (oxLDL/b2GPI) with normal and dyslipidemic subjects with described familial CVD histories.

Material and methods
A total of 188 subjects were enrolled [dyslipidemic (n103) and normal (n88)]. Clinical assessment, lipid profile and serum ELISA analysis of oxLDL/b2GPI were measured.

Results
A statistically significant difference (P < 0.01) in mean serum concentration of oxLDL/b2GPI was observed for normal (2.29 U/mle6.48 U/ml with a mean of 4.32 U/ml) vs dyslipidemic (3.98 U/mle7.99 U/ml with a mean of 6.04 U/ml) The percent of normal lipid subjects with a family history of CVD was 21.6 % whereas it was 25.2 % for dyslipidemic subjects, which was not statistically different (P < 0.05). The mean oxLDL/b2GPI concentrations for subjects without a family history of CVD were 4.94 U/ml vs 6.28 U/ml for subjects with a family history of CVD history which were statistically different (P < 0.05).

Conclusion
The oxidative marker oxLDL/b2GPI was significantly elevated in dyslipidemic subjects and correlated with family history of CVD increasing its potential as an additional independent marker for predicting cardiovascular disease in India.

Source: Journal of Indian college of cardiology 3 (2013) 159-162